Nested case-control studies using two U.K. primary care databases found that oral hormone replacement therapy was associated with a significantly increased risk for venous thromboembolism (VTE), while transdermal formulations were not.
The seventh edition of the ACP Ethics Manual reaffirms ethical tenets of medicine and reexamines their application in changing circumstances.
A 35-year-old woman is evaluated for constipation. She reports passage of hard stool every 3 to 4 days and associated bloating. Her symptoms have been present for more than 10 years and have progressed gradually. On physical examination, vital signs and other findings are normal. What is the most appropriate treatment?
Statins, calcium-channel blockers, and metformin are globally licensed, commonly used, inexpensive, and relatively safe, and therefore “ideal candidates for repurposing” for mental illness, the study authors wrote.
Naloxone can reverse the effects of an opioid overdose if it is quickly administered.
Political unrest and violence in Nicaragua have reportedly led the government to impede the provision of care to wounded protesters, with physicians being subject to arbitrary firings and orders not to treat demonstrators.