Search results for "Gout"
Cardiovascular safety of febuxostat and allopurinol compared in patients with gout and CVD
In a modified intention-to-treat analysis, the primary end point of first occurrence of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or urgent revascularization for unstable angina occurred in 10.8% of patients taking febuxostat and in 10.4% of patients taking allopurinol (hazard ratio, 1.03).
https://immattersacp.org/weekly/archives/2018/03/20/4.htm
20 Mar 2018
Use caution with colchicine's many drug interactions
A coauthor of “The Top 100 Drug Interactions” offers advice for improved management of colchicine.
https://immattersacp.org/archives/2023/09/use-caution-with-colchicines-many-drug-interactions.htm
1 Sep 2023
Corticosteroids may be viable first-line alternative to NSAIDs for acute gout
The study provides evidence that oral corticosteroids are as effective at treating pain and as acceptable to patients as non-steroidal anti-inflammatory drugs, and that they should be considered as a first-line alternative in the treatment of patients with acute gout.
https://immattersacp.org/weekly/archives/2016/02/23/4.htm
23 Feb 2016
MKSAP Quiz: 5-year history of recurrent gout
A 53-year-old man is evaluated for a 5-year history of recurrent gout attacks involving the base of the great toes, mid feet, and ankles. Episodes are becoming more frequent and severe. History is also significant for hypertension and stage 3 chronic kidney disease. Following a physical exam and lab studies, what is the most appropriate next step in management?
https://immattersacp.org/weekly/archives/2018/12/11/3.htm
11 Dec 2018
MKSAP Quiz: follow-up visit for gout
A 55-year-old man is evaluated during a follow-up visit for gout. Two years ago, he had been treated with allopurinol and developed a hypersensitivity reaction. Over the past several months, he has had recurrent attacks of acute, episodic swelling of the first metatarsophalangeal joints with increasing involvement of other joints, including the ankles and knees. Laboratory studies showed significant hyperuricemia. History is also significant for Crohn disease, hypertension, chronic kidney disease (estimated glomerular filtration rate of 55 mL/min/1.73 m2), and nonalcoholic fatty liver disease. Current medications are diltiazem and azathioprine, which he has been taking for the past 9 months. Which of these is a contraindication to the use of febuxostat in this patient?
https://immattersacp.org/weekly/archives/2017/01/24/3.htm
24 Jan 2017
Gout drug concerns; monthly buprenorphine injection OK'd
This column reviews details on recent recalls, warnings, and approvals.
https://immattersacp.org/archives/2018/02/gout-drug-concerns-monthly-buprenorphine-injection-okd.htm
1 Feb 2018
Studies analyze causes of hyperuricemia, kidney effects of gout treatment with allopurinol
Genetics contribute more than diet to hyperuricemia in healthy people, and 300 mg of allopurinol per day was associated with lower risk of chronic kidney disease in people with gout, recent research found.
https://immattersacp.org/weekly/archives/2018/10/16/1.htm
16 Oct 2018
MKSAP Quiz: Gout with flares
This week's quiz asks readers to determine the appropriate next step in management for a 59-year-old man with a 6-month history of gout, hypersensitivity to allopurinol, and more frequent gout flares.
https://immattersacp.org/weekly/archives/2015/09/15/3.htm
15 Sep 2015
Helping patients manage generic drug price increases
Generic drugs have recently become more expensive, from colchicine for gout to EpiPens for allergic reactions. Physicians are having trouble managing patients when their medicines suddenly rise in price.
https://immattersacp.org/archives/2019/09/helping-patients-manage-generic-drug-price-increases.htm
1 Sep 2019
Clinical practice guideline for acute gout recommends corticosteroids, NSAIDs, low-dose colchicine
For diagnosis, a separate guideline recommended that physicians use synovial fluid analysis when clinical judgment indicates that diagnostic testing is necessary in patients with possible gout.
https://immattersacp.org/weekly/archives/2016/11/01/1.htm
1 Nov 2016