Answers to clues are placed horizontally in rows to reveal an answer written vertically. Unlike the familiar acrostic puzzle format, the final answer can be in any column.
1) Common cause of benign bili bump
Find in the vertical columns: Not a handsome disorder. The puzzle grid is Table 1.
Bonus clue, find in the vertical columns: Knuckle down for the answer
Answer: Buerger's disease
The answer grid is Table 2. Buerger's disease (thromboangiitis obliterans) is a vascular disorder characterized by acral tissue loss on the hands. Acute inflammation and clotting of the arteries and veins of the hands and feet can cause critical limb ischemia and/or claudication, rest pain, and non-healing sores or ulcers in the hands and/or feet.
Buerger's disease, which occurs almost exclusively in heavy smokers, is treatable only by stopping smoking and other tobacco use. Failure to do so can result in amputation. (Information from the University of California, Davis Vascular Center. )
Bonus answer: Gottron's papules
Gottron papules are erythematous to slightly violaceous papules over the bony prominences of the hands and fingers associated with dermatomyositis. Gottron sign is macular erythema over the extensor surfaces, particularly the interphalangeal joints or elbows and knees. Dermatomyositis is an idiopathic inflammatory myopathy with a peak incidence in patients between 40 and 60 years of age. An increased association with malignancy has been noted with dermatomyositis. Initial therapy is with glucocorticoids. (Information adapted from MKSAP 16.)